The goal of this work is to identify mouse receptors that are ideally
specific, or at least enriched in mMO germ cells
In the analysis below, we:
1. read in the
mMO151_MFTAv2.2_mouse_final.RDS
2. inspect the labeled cell
types
3. subset the data to cell types of interest
4. perform
top marker identification
5. perform differential expression
analysis
Because of few germ cells across mMO151, will keep d4 and d6 mMOs
together for downstream analyses
We find that Tex101 is a specific marker of germ cells in both the fetal
atlas and mMO151
Note that partition 2 in mMO151 corresponds to
PGC/Germ cells
Plots above show the Top 5 markers
While Tex101 appears to be a specific marker of germ cells, can we
identify other receptors that are
significantly enriched among germ
cells?